Non-canonical functions of the RB protein in cancer.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 29692417.
- Also identified by DOI 10.1038/s41568-018-0008-5 and PMC identifier 6693677.
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Abstract
The canonical model of RB-mediated tumour suppression developed over the past 30 years is based on the regulation of E2F transcription factors to restrict cell cycle progression. Several additional functions have been proposed for RB, on the basis of which a non-canonical RB pathway can be described. Mechanistically, the non-canonical RB pathway promotes histone modification and regulates chromosome structure in a manner distinct from cell cycle regulation. These functions have implications for chemotherapy response and resistance to targeted anticancer agents. This Opinion offers a framework to guide future studies of RB in basic and clinical research.
Medical subject headings
- Chromosome Structures
- Drug Resistance, Neoplasm
- Histone Code
- Neoplasms
- Retinoblastoma Protein