Matrix protein tenascin-C expands and reversibly blocks maturation of murine eosinophil progenitors.
Level V
Where this comes from
- Record sourced from PubMed, PMID 29705244.
- Also identified by DOI 10.1016/j.jaci.2018.02.054 and PMC identifier 6737931.
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Abstract
We show that Tenascin-C, an asthma-associated extracellular matrix glycoprotein, promotes hematopoietic progenitors and suppresses the IL-5-driven maturation of murine lung eosinophils. The extracellular matrix’s regulation of <i>in situ</i> hematopoiesis has significant implications for targeting tissue eosinophils.
Medical subject headings
- Eosinophils
- Extracellular Matrix
- Granulocyte Precursor Cells
- Hypersensitivity
- Pneumonia
- Tenascin