5-HT2a receptor in mPFC influences context-guided reconsolidation of object memory in perirhinal cortex.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29717980.
- Also identified by DOI 10.7554/eLife.33746 and PMC identifier 5931799.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Context-dependent memories may guide adaptive behavior relaying in previous experience while updating stored information through reconsolidation. Retrieval can be triggered by partial and shared cues. When the cue is presented, the most relevant memory should be updated. In a contextual version of the object recognition task, we examined the effect of medial PFC (mPFC) serotonin 2a receptor (5-HT2aR) blockade during retrieval in reconsolidation of competing objects memories. We found that mPFC 5-HT2aR controls retrieval and reconsolidation of object memories in the perirhinal cortex (PRH), but not in the dorsal hippocampus in rats. Also, reconsolidation of objects memories in PRH required a functional interaction between the ventral hippocampus and the mPFC. Our results indicate that in the presence of conflicting information at retrieval, mPFC 5-HT2aR may facilitate top-down context-guided control over PRH to control the behavioral response and object memory reconsolidation.
Medical subject headings
- Hippocampus
- Memory
- Perirhinal Cortex
- Prefrontal Cortex
- Receptor, Serotonin, 5-HT2A