Increased Systemic Inflammation and Gut Permeability Among Women With Treated HIV Infection in Rural Uganda.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 29718342.
- Also identified by DOI 10.1093/infdis/jiy244 and PMC identifier 6093434.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
In a cohort of human immunodeficiency virus (HIV)-infected individuals and age- and sex-matched HIV-uninfected comparators, we assessed soluble CD14 (sCD14), sCD163, interleukin 6, intestinal fatty acid binding protein (IFAPB), and high-sensitivity C-reactive protein (hs-CRP) levels. The median age was 51 years. Among HIV-positive individuals, the median antiretroviral therapy (ART) duration was 7 years, the median CD4+ T-cell count was 433 cells/μL, and 86% had an undetectable viral load. Although HIV-positive individuals had higher sCD14, IFABP, and hs-CRP levels, we found evidence of interaction by sex, such that HIV-positive women had greater differences from HIV-negative women, compared with differences between HIV-positive men and HIV-negative men. In models restricted to HIV-positive individuals, women had higher levels of all 5 biomarkers than men.
Medical subject headings
- Anti-Retroviral Agents
- Antigens, CD
- Antigens, Differentiation, Myelomonocytic
- C-Reactive Protein
- Fatty Acid-Binding Proteins
- HIV Infections
- Interleukin-6
- Lipopolysaccharide Receptors
- Receptors, Cell Surface