Improved enzyme annotation with EC-specific cutoffs using DETECT v2.
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- Record sourced from PubMed, PMID 29722785.
- Also identified by DOI 10.1093/bioinformatics/bty368 and PMC identifier 6157075.
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Abstract
We present DETECT v2-an enzyme annotation tool which considers the effect of sequence diversity when assigning enzymatic function [as an Enzyme Commission (EC) number] to a protein sequence. In addition to capturing more enzyme classes than the previous version, we now provide EC-specific cutoffs that greatly increase precision and recall of assignments and show its performance in the context of pathways. https://github.com/ParkinsonLab/DETECT-v2. Supplementary data are available at Bioinformatics online.
Medical subject headings
- Enzymes
- Software