Joint Reconstruction of Tracer Distribution and Background in Magnetic Particle Imaging.

Abstract

Magnetic particle imaging (MPI) is a novel tomographic imaging technique, which visualizes the distribution of a magnetic nanoparticle-based tracer material. However, reconstructed MPI images often suffer from an insufficiently compensated image background caused by rapid non-deterministic changes in the background signal of the imaging device. In particular, the signal-to-background ratio (SBR) of the images is reduced for lower tracer concentrations or longer acquisitions. The state-of-the-art procedure in MPI is to frequently measure the background signal during the sample measurement. Unfortunately, this requires a removal of the entire object from the scanner's field of view (FOV), which introduces dead time and repositioning artifacts. To overcome these considerable restrictions, we propose a novel method that uses two consecutive image acquisitions as input parameters for a simultaneous reconstruction of the tracer distribution, as well as the background signal. The two acquisitions differ by just a small spatial shift, while keeping the object always within the focus of a slightly reduced FOV. A linearly interpolated background between the initial and final background measurement is used to seed the iterative reconstruction. The method has been tested with simulations and phantom measurements. Overall, a substantial reduction of the image background was observed, and the image SBR is increased by a factor of 2(7) for the measurement (simulation) data.