Direct Visualization of Wide Fusion-Fission Pores and Their Highly Varied Dynamics.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29727670.
- Also identified by DOI 10.1016/j.cell.2018.04.016 and PMC identifier 6475904.
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Abstract
In this issue of Cell, Shin et al. report the first live-cell imaging of a fusion pore. Directly visualized pores in neuroendocrine cells can be much larger than expected yet not require vesicular full-collapse. These fusion-fission pores have diverse fates arising from opposing dynamin-driven pore constriction and F-actin-mediated pore expansion.
Medical subject headings
- Chromaffin Cells
- Endocytosis