HippoCA3mpal Stem Cell Models Expose Dysfunctional Circuits in Schizophrenia.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29727672.
- Also identified by DOI 10.1016/j.stem.2018.04.008 and PMC identifier 6192513.
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Abstract
In this issue of Cell Stem Cell, Sarkar et al. (2018) describe an efficient method for the generation of human hippocampal pyramidal neurons from stem cells. They developed a compelling in vitro model that recapitulates synaptic connectivity within the hippocampus and showed that cells derived from patients with schizophrenia exhibit abnormal electrical activity.
Medical subject headings
- Pluripotent Stem Cells
- Schizophrenia