Crinkle-Cut Brain Organoids.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 29727676.
- Also identified by DOI 10.1016/j.stem.2018.04.011.
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Abstract
In large mammalian brains, including those of humans, the surface of the cortex is highly folded. How these convolutions form is still unclear, but recent work in Nature Physics by Karzbrun et al. (2018) supports a mechanism involving differential surface swelling combined with internal constraint.