A viral protein kinase drug target for tumors?
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29733293.
- Also identified by DOI 10.1172/JCI121080 and PMC identifier 5983323.
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Abstract
The human gammaherpesviruses, Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV), are both associated with tumors. Standard antiviral therapies are ineffective at treating these tumors. A serine/threonine kinase important for viral replication is conserved across the herpesviruses. Expression of the KSHV protein kinase in transgenic mice under the control of a ubiquitin promoter was associated with B cell lymphoproliferative disease and lymphoma. If the viral protein kinase is important in the pathogenesis of KSHV lymphoproliferative disease or lymphoma, the kinase may present a very good target for pharmacologic therapies.
Medical subject headings
- Herpesvirus 8, Human
- Lymphoma, B-Cell