Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 29739929.
- Also identified by DOI 10.1038/s41467-018-04086-y and PMC identifier 5940788.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The skin's tendency to sunburn rather than tan is a major risk factor for skin cancer. Here we report a large genome-wide association study of ease of skin tanning in 176,678 subjects of European ancestry. We identify significant association with tanning ability at 20 loci. We confirm previously identified associations at six of these loci, and report 14 novel loci, of which ten have never been associated with pigmentation-related phenotypes. Our results also suggest that variants at the AHR/AGR3 locus, previously associated with cutaneous malignant melanoma the underlying mechanism of which is poorly understood, might act on disease risk through modulation of tanning ability.
Medical subject headings
- Carrier Proteins
- Genetic Loci
- Neoplasm Proteins
- Receptors, Aryl Hydrocarbon
- Sunburn
- Suntan
- White People