Construction of versatile multilayered composite nanoparticles from a customized nanogel template.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29744445.
- Also identified by DOI 10.1016/j.bioactmat.2017.06.003 and PMC identifier 5935661.
- Licence recorded as CC BY-NC-ND.
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Abstract
We present a highly adaptable design platform for multi-responsive, multilayered composite nanoparticles (MC-NPs) with fine-tunable functional layers. A flexible disulfide-linked nanogel template is obtained by a controlled <i>in-situ</i> gelation method, enabling a high degree of control over each successive layer. From this template, we optimize "smart" biomaterials with biofunctional surfaces, tunable drug release kinetics, and magnetic or pH-responsive functionality, fabricated into MC-NPs for targeted drug release and periosteum-mimetic structures for controlled rhBMP-2 release towards bone tissue formation <i>in-vivo</i>. Such a versatile platform for the design of MC-NPs is a powerful tool that shows considerable therapeutic potential in clinical fields such as oncology and orthopedics.