Nitric Oxide-Releasing Macromolecular Scaffolds for Antibacterial Applications.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 29756275.
- Also identified by DOI 10.1002/adhm.201800155 and PMC identifier 6159924.
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Abstract
Exogenous nitric oxide (NO) represents an attractive antibacterial agent because of its ability to both disperse and directly kill bacterial biofilms while avoiding resistance. Due to the challenges associated with administering gaseous NO, NO-releasing macromolecular scaffolds are developed to facilitate NO delivery. This progress report describes the rational design and application of NO-releasing macromolecular scaffolds as antibacterial therapeutics. Special consideration is given to the role of the physicochemical properties of the NO storage vehicles on antibacterial or anti-biofilm activity.
Medical subject headings
- Anti-Bacterial Agents
- Macromolecular Substances
- Nitric Oxide
- Nitric Oxide Donors