Fluorescent 2D WS<sub>2</sub> Nanosheets Bearing Chemical Affinity Elements for the Recognition of Glycated Hemoglobin.
basic_science · Level V
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- Record sourced from PubMed, PMID 29761643.
- Also identified by DOI 10.1002/adhm.201701496.
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Abstract
It is required to exfoliate and functionalize 2D transition metal dichalcogenides (TMDs) in an aqueous solution for biological and medical applications. Herein, the approach for the simultaneous exfoliation and functionalization of 2D WS<sub>2</sub> nanosheets using boronic acid-modified poly(vinyl alcohol) (B-PVA) in an aqueous solution is reported, and the B-PVA-functionalized WS<sub>2</sub> nanosheets (B-PVA-WS<sub>2</sub> ) are exploited as a fluorescent biosensor for the detection of glycated hemoglobin, HbA1c. The synthetic B-PVA polymer facilitates the exfoliation and functionalization of WS<sub>2</sub> nanosheets from the bulk counterpart in the aqueous solution via a pulsed sonication process, resulting in fluorescent B-PVA-WS<sub>2</sub> nanohybrids with a specific recognition of HbA1c. The fluorescence of the B-PVA-WS<sub>2</sub> is quenched in the presence of HbA1c, whereas PVA-functionalized WS<sub>2</sub> (PVA-WS<sub>2</sub> ), not bearing boronic acid as a recognition moiety, shows no fluorescence changes upon the addition of the target. The B-PVA-WS<sub>2</sub> is able to selectively detect HbA1c at the concentration as low as 3.3 × 10<sup>-8</sup> m based on its specific fluorescence quenching.
Medical subject headings
- Biosensing Techniques
- Glycated Hemoglobin
- Nanostructures