Effect of Antiretroviral Therapy on Plasma Concentrations of Chloroquine and Desethyl-chloroquine.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 29771277.
- Also identified by DOI 10.1093/cid/ciy405 and PMC identifier 6206114.
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Abstract
The effect of antiretroviral therapy (ART) on chloroquine and desethyl-chloroquine plasma concentrations was evaluated in clinical trial participants. Concentrations did not differ among participants receiving protease inhibitor-based ART (n = 9), efavirenz-based ART (n = 15), or other ART (n = 8) and those not receiving ART (n = 31). Efavirenz seemed to inhibit chloroquine desethylation.
Medical subject headings
- Anti-Retroviral Agents
- Antimalarials
- Chloroquine
- HIV Infections
- Malaria