Better Together: A Hybrid Amyloid Signals Necroptosis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29775589.
- Also identified by DOI 10.1016/j.cell.2018.04.030.
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Abstract
A new solid-state NMR study determines the high-resolution hetero-amyloid structure of the RIPK1-RIPK3 signaling complex that is involved in mediating necroptosis. The structure demonstrates specific formation of hetero-amyloids over homo-amyloids and the structural basis for a functional amyloid to act as a platform to recruit and activate downstream partners in intracellular signaling.
Medical subject headings
- Necrosis
- Receptor-Interacting Protein Serine-Threonine Kinases