Accuracy of Herpes Simplex Virus Polymerase Chain Reaction Testing of the Blood for Central Nervous System Herpes Simplex Virus Infections in Infants.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 29784511.
- Also identified by DOI 10.1016/j.jpeds.2018.04.061.
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Abstract
There were 1038 infants with herpes simplex virus polymerase chain reaction testing performed of blood and cerebrospinal fluid specimens. There were 21 (2.0%) with a positive cerebrospinal fluid PCR, of whom 16 also had a positive blood PCR (sensitivity 76%; 95% CI, 53%-92%). Blood PCR cannot exclude herpes simplex virus central nervous system infection.
Medical subject headings
- Central Nervous System Viral Diseases
- DNA, Viral
- Herpes Simplex
- Polymerase Chain Reaction
- Simplexvirus