Toward individual glomerular phenotyping: advent of precision medicine in kidney biopsies.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29792268.
- Also identified by DOI 10.1016/j.kint.2018.01.035 and PMC identifier 6583000.
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Abstract
The road to precision medicine for nephrology is approaching quickly. In the present volume, the glomerular proteome has now been characterized at a single glomerulus level in mouse and human kidneys. Using the Single-Pot Solid-Phase-enhanced Sample Preparation (SP3) approach the authors demonstrated that LAMP1 is a key lysosomal protein that is increased in glomerular diseases and may play a pathogenic role.
Medical subject headings
- Kidney Glomerulus
- Precision Medicine