Cancer metabolism gets physical.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 29794058.
- Also identified by DOI 10.1126/scitranslmed.aaq1011 and PMC identifier 5990021.
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Abstract
Patient-derived culture models enable assessment of drug sensitivity and can connect personalized genomics with therapeutic options. However, their clinical translation is constrained by limited fidelity. We outline how the physical microenvironment regulates cell metabolism and describe how engineered culture systems could enhance the predictive power for precision medicine.
Medical subject headings
- Biophysical Phenomena
- Neoplasms