Soluble Macrophage Mannose Receptor (sCD206/sMR) as a Biomarker in Human Immunodeficiency Virus Infection.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 29800140.
- Also identified by DOI 10.1093/infdis/jiy318.
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Abstract
Macrophages play important roles during human immunodeficiency virus (HIV) infection, reflected by changes in macrophage-activation biomarker soluble CD163 (sCD163). Here, we present data on the novel macrophage-activation biomarker soluble mannose receptor/CD206 (sCD206) in HIV infection. We investigated sCD206 blood levels at baseline and follow-up with/without antiretroviral therapy (ART), in 212 patients with HIV type 1 (HIV-1), HIV type 2 (HIV-2), or dual infection. At baseline, there was no difference in sCD206 level between HIV types, and sCD206 was unchanged at follow-up without ART. However, in contrast to sCD163, sCD206 levels decreased significantly for both HIV-1 and HIV-2, but not for HIV-1/2 patients, during ART. Further investigations are needed to establish sCD206 as a biomarker in HIV infection.
Medical subject headings
- Anti-HIV Agents
- HIV Infections
- HIV-1
- HIV-2
- Lectins, C-Type
- Macrophages
- Mannose-Binding Lectins
- Receptors, Cell Surface