The role of dynamic enzyme assemblies and substrate channelling in metabolic regulation.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 29849027.
- Also identified by DOI 10.1038/s41467-018-04543-8 and PMC identifier 5976638.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Transient physical association between enzymes appears to be a cardinal feature of metabolic systems, yet the purpose of this metabolic organisation remains enigmatic. It is generally assumed that substrate channelling occurs in these complexes. However, there is a lack of information concerning the mechanisms and extent of substrate channelling and confusion regarding the consequences of substrate channelling. In this review, we outline recent advances in the structural characterisation of enzyme assemblies and integrate this with new insights from reaction-diffusion modelling and synthetic biology to clarify the mechanistic and functional significance of the phenomenon.
Medical subject headings
- Allosteric Regulation
- Energy Metabolism
- Enzymes
- Models, Biological