A "Counter-Enhancer" in Tumor Suppression.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29856950.
- Also identified by DOI 10.1016/j.cell.2018.05.023.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The role of the noncoding genome in cancer biology is continually expanding. Cho et al. reveal a new and unexpected mechanism for the regulation of MYC expression mediated by the promoter sequence of its neighbor gene PVT1. This DNA element acts as a promoter-enhancer competitor and a candidate tumor suppressor.
Medical subject headings
- Promoter Regions, Genetic
- RNA, Long Noncoding