Intestinal Stem Cell Dynamics: A Story of Mice and Humans.
editorial · Level V
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- Record sourced from PubMed, PMID 29859166.
- Also identified by DOI 10.1016/j.stem.2018.05.005.
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Abstract
Stem cell dynamics define the probability of accumulating mutations within the intestinal epithelium. In this issue of Cell Stem Cell, Nicholson et al. (2018) report that human intestinal stem cell dynamics differ significantly from those of mice and establish that oncogenic mutations are more likely to expand; therefore, "normal" epithelium may carry multiple mutations.
Medical subject headings
- Intestinal Mucosa
- Intestines