Mesenchymal Stromal Cells: Clinical Challenges and Therapeutic Opportunities.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 29859173.
- Also identified by DOI 10.1016/j.stem.2018.05.004 and PMC identifier 6434696.
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Abstract
Mesenchymal stromal cells (MSCs) have been the subject of clinical trials for more than a generation, and the outcomes of advanced clinical trials have fallen short of expectations raised by encouraging pre-clinical animal data in a wide array of disease models. In this Perspective, important biological and pharmacological disparities in pre-clinical research and human translational studies are highlighted, and analyses of clinical trial failures and recent successes provide a rational pathway to MSC regulatory approval and deployment for disorders with unmet medical needs.
Medical subject headings
- Graft vs Host Disease
- Mesenchymal Stem Cell Transplantation
- Mesenchymal Stem Cells