Regenerating Eye Tissues to Preserve and Restore Vision.
review · Level V
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- Record sourced from PubMed, PMID 29859174.
- Also identified by DOI 10.1016/j.stem.2018.05.013 and PMC identifier 6492284.
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Abstract
Ocular regenerative therapies are on track to revolutionize treatment of numerous blinding disorders, including corneal disease, cataract, glaucoma, retinitis pigmentosa, and age-related macular degeneration. A variety of transplantable products, delivered as cell suspensions or as preformed 3D structures combining cells and natural or artificial substrates, are in the pipeline. Here we review the status of clinical and preclinical studies for stem cell-based repair, covering key eye tissues from front to back, from cornea to retina, and including bioengineering approaches that advance cell product manufacturing. While recognizing the challenges, we look forward to a deep portfolio of sight-restoring, stem cell-based medicine. VIDEO ABSTRACT.
Medical subject headings
- Cornea
- Eye Diseases
- Regeneration
- Retina
- Stem Cells
- Vision, Ocular