Therapeutic and protective efficacy of a dengue antibody against Zika infection in rhesus monkeys.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29867228.
- Also identified by DOI 10.1038/s41591-018-0056-0 and PMC identifier 5992501.
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Abstract
Strategies to treat Zika virus (ZIKV) infection in dengue virus (DENV)-endemic areas are urgently needed. Here we show that a DENV-specific antibody against the E-dimer epitope (EDE) potently cross-neutralizes ZIKV and provides robust therapeutic efficacy as well as prophylactic efficacy against ZIKV in rhesus monkeys. Viral escape was not detected, suggesting a relatively high bar to escape. These data demonstrate the potential for antibody-based therapy and prevention of ZIKV.
Medical subject headings
- Antibodies, Viral
- Dengue
- Zika Virus
- Zika Virus Infection