Irreversible temperature gating in trpv1 sheds light on channel activation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29869983.
- Also identified by DOI 10.7554/eLife.36372 and PMC identifier 5999395.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Temperature-activated TRP channels or thermoTRPs are among the only proteins that can directly convert temperature changes into changes in channel open probability. In spite of a wealth of functional and structural information, the mechanism of temperature activation remains unknown. We have carefully characterized the repeated activation of TRPV1 by thermal stimuli and discovered a previously unknown inactivation process, which is irreversible. We propose that this form of gating in TRPV1 channels is a consequence of the heat absorption process that leads to channel opening.
Medical subject headings
- Ion Channel Gating
- Membrane Potentials
- TRPV Cation Channels