OXPHOS Defects Due to mtDNA Mutations: Glutamine to the Rescue!
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 29874564.
- Also identified by DOI 10.1016/j.cmet.2018.05.010.
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Abstract
Mutations in mtDNA associated with OXPHOS defects preclude energy harnessing by OXPHOS. The work of Chen et al. (2018) is previewed, reporting flux pathways of glutamine catabolism in mtDNA mutant cells yielding high-energy phosphates through substrate-level phosphorylation and the influence exerted by the severity of OXPHOS impairment.
Medical subject headings
- DNA, Mitochondrial
- Glutamine