Highly Attenuated Infection With a Vpr-Deleted Molecular Clone of Human Immunodeficiency Virus-1.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 29878133.
- Also identified by DOI 10.1093/infdis/jiy346 and PMC identifier 6151090.
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Abstract
A 48-year-old woman was infected with a vpr-defective human immunodeficiency virus (HIV)-1 molecular clone. Seroconversion was markedly delayed, and without treatment she had durably suppressed viremia and normal T-cell levels. Neutralizing antibody and CD8+ T-cell immune responses against HIV-1 were unremarkable. Viral sequences confirmed the source but evolved defective nef, suggesting an unknown mechanistic link to vpr. There were subtle qualitative defects in T and B cells. To our knowledge, this is the only case of human infection with a characterized defective HIV-1 molecular clone, which furthermore recapitulated live-attenuated vaccination in macaque models of HIV-1 vaccine research.
Medical subject headings
- AIDS Vaccines
- Gene Products, vpr
- HIV Infections
- HIV-1
- Vaccines, Attenuated