Biomimetic O<sub>2</sub>-Evolving metal-organic framework nanoplatform for highly efficient photodynamic therapy against hypoxic tumor.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29913389.
- Also identified by DOI 10.1016/j.biomaterials.2018.06.007.
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Abstract
Improving the supply of O<sub>2</sub> and the circulation lifetime of photosensitizers for photodynamic therapy (PDT) in vivo would be a promising approach to eliminate hypoxic tumors. Herein, by taking advantage of the significant gas-adsorption capability of metal-organic frameworks (MOFs), a biomimetic O<sub>2</sub>-evolving photodynamic therapy (PDT) nanoplatform with long circulating properties was fabricated. Zirconium (IV)-based MOF (UiO-66) was used as a vehicle for O<sub>2</sub> storing, then conjugated with indocyanine green (ICG) by coordination reaction, and further coated with red blood cell (RBC) membranes. Upon 808 nm laser irradiation, the initial singlet oxygen (<sup>1</sup>O<sub>2</sub>) generated by ICG would decompose RBC membranes. At the same time, The photothermal property of ICG could facilitate the burst release of O<sub>2</sub> from UiO-66. Subsequently, the generated O<sub>2</sub> could significantly improve the PDT effects on hypoxic tumor. Owing to the advantages of long circulation and O<sub>2</sub> self-sufficient, the designed nanotherapeutic agent can improve the efficiency of treatment against hypoxia tumor via PDT. Hence, this study presents a new paradigm for co-delivery of O<sub>2</sub> and photosensitizers, and provides a new avenue to eliminate hypoxic tumors.
Medical subject headings
- Biomimetic Materials
- Metal-Organic Frameworks
- Nanoparticles
- Oxygen
- Photochemotherapy
- Tumor Hypoxia