Association of Interindividual Variation in Plasma Oxytocin With Postcesarean Incisional Pain.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 29916862.
- Also identified by DOI 10.1213/ANE.0000000000003567.
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Abstract
Oxytocin has known antinociceptive effects and is upregulated perinatally. This pilot study investigated the association of plasma oxytocin and postcesarean incisional pain. Plasma samples from 18 patients undergoing elective cesarean delivery were drawn at 1 hour preoperatively and 1 and 24 hours postoperatively and analyzed by using enzyme-linked immunosorbent assay. Pain was assessed at 1 day, 8 weeks, 3 months, and 6 months postoperatively. Incisional pain at 24 hours was inversely correlated with 1- and 24-hour oxytocin levels, with higher plasma oxytocin associated with lower pain (ρ, -0.52 and -0.66; P < .05).
Medical subject headings
- Biological Variation, Population
- Cesarean Section
- Oxytocin
- Postoperative Pain