Microfluidics-enabled rational design of immunomagnetic nanomaterials and their shape effect on liquid biopsy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29923569.
- Also identified by DOI 10.1039/c8lc00273h and PMC identifier 6071334.
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Abstract
Microfluidics brings unique opportunities for the synthesis of nanomaterials toward efficient liquid biopsy. Herein, we developed the microreactor-enabled flow synthesis of immunomagnetic nanomaterials with controllable shapes (sphere, cube, rod, and belt) by simply tuning the flow rates. The particle shape-dependent screening efficiency of circulating tumor cells was first investigated and compared with commercial ferrofluids, providing new insights into the rational design of a particulate system toward the screening and analysis of circulating tumor biomarkers.
Medical subject headings
- Immunomagnetic Separation
- Lab-On-A-Chip Devices
- Liquid Biopsy
- Nanostructures