Genetic Mosaics for Greater Precision in Cardiovascular Research.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 29929974.
- Also identified by DOI 10.1161/CIRCRESAHA.118.313386 and PMC identifier 6025841.
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Abstract
Interpretation of cardiac gain- and loss- of function experiments are prone to secondary, indirect effects that confound and obscure data interpretation. We advocate the use of a genetic mosaic strategy to circumvent these issues and increase precision in cardiovascular research.
Medical subject headings
- Biomedical Research
- Gene Knockout Techniques
- Models, Genetic
- Myocytes, Cardiac