Comment on "Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death".
Level V
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- Record sourced from PubMed, PMID 29930109.
- Also identified by DOI 10.1126/science.aar6910 and PMC identifier 7045345.
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Abstract
Shlezinger <i>et al</i> (Reports, 8 September 2017, p. 1037) report that the common fungus <i>Aspergillus fumigatus</i>, a cause of aspergillosis, undergoes caspase-dependent apoptosis-like cell death triggered by lung neutrophils. However, the technologies they used do not provide reliable evidence that fungal cells die via a protease signaling cascade thwarted by a fungal caspase inhibitor homologous to human survivin.
Medical subject headings
- Aspergillosis
- Aspergillus fumigatus