Response to Comment on "Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death".
other · Level V
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- Record sourced from PubMed, PMID 29930111.
- Also identified by DOI 10.1126/science.aas9457 and PMC identifier 6752710.
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Abstract
Aouacheria <i>et al</i> question the interpretation of contemporary assays to monitor programmed cell death with apoptosis-like features (A-PCD) in <i>Aspergillus fumigatus</i> Although our study focuses on fungal A-PCD for host immune surveillance and infectious outcomes, the experimental approach incorporates multiple independent A-PCD markers and genetic manipulations based on fungal rather than mammalian orthologs to circumvent the limitations associated with any single approach.
Medical subject headings
- Apoptosis
- Fungi