IgA nephropathy: new insights into the role of complement.

Floege, Jürgen; Daha, Mohamed R · Kidney Int · 2018

editorial · Level V

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Abstract

Glomerular complement deposition is common in IgA nephropathy, and recent genome-wide association studies point to a role of complement factor H and complement factor H-related proteins in disease susceptibility. A number of recent studies have now documented elevated levels of some factor H-related proteins in IgA nephropathy, which might contribute to enhanced complement activation.

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