Comment on 'YcgC represents a new protein deacetylase family in prokaryotes'.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 29939131.
- Also identified by DOI 10.7554/eLife.37798 and PMC identifier 6023612.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Lysine acetylation is a post-translational modification that is conserved from bacteria to humans. It is catalysed by the activities of lysine acetyltransferases, which use acetyl-CoA as the acetyl-donor molecule, and lysine deacetylases, which remove the acetyl moiety. Recently, it was reported that YcgC represents a new prokaryotic deacetylase family with no apparent homologies to existing deacetylases (Tu et al., 2015). Here we report the results of experiments which demonstrate that YcgC is not a deacetylase.
Medical subject headings
- Lysine
- Protein Processing, Post-Translational