Dissecting the mammary gland one cell at a time.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29946144.
- Also identified by DOI 10.1038/s41467-018-04905-2 and PMC identifier 6018702.
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Abstract
Dissecting cellular differentiation hierarchies in the mammary gland is a prerequisite for understanding both normal development and malignant transformation during tumorigenesis and tumor cell-of-origin. To achieve these goals, several recent papers utilized single cell RNA-seq and lineage tracing to improve our understanding of the composition of the mammary epithelium at different developmental stages.
Medical subject headings
- Mammary Glands, Animal
- Mammary Glands, Human