Association of TNF-α-308 G > A and -238G > A polymorphisms with knee osteoarthritis risk: A case-control study and meta-analysis.
meta_analysis · Level I
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- Record sourced from PubMed, PMID 29946197.
- Also identified by DOI 10.1016/j.jor.2018.05.047 and PMC identifier 6014562.
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Abstract
A comprehensive search on electronic databases was conducted to identify all eligible studies of TNF-α polymorphisms and knee osteoarthritis (OA). Eight studies on TNF-α -308 G > A and three on TNF-α -238G > A polymorphism were identified. Overall, the pooled ORs indicated that neither TNF-α -238G > A nor -238G > A polymorphism was associated with knee OA risk. Similarly, in the stratified analysis by ethnicity, no significant association was found. This meta-analysis results inconsistent with the previous meta-analyses showed that the TNF-α -308 G > A and -238G > A polymorphisms may not be associated with the susceptibility to knee OA.
Anatomy
- knee