2D transition metal dichalcogenides with glucan multivalency for antibody-free pathogen recognition.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29959329.
- Also identified by DOI 10.1038/s41467-018-04997-w and PMC identifier 6026184.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The ability to control the dimensions and properties of nanomaterials is fundamental to the creation of new functions and improvement of their performances in the applications of interest. Herein, we report a strategy based on glucan multivalent interactions for the simultaneous exfoliation and functionalization of two-dimensional transition metal dichalcogenides (TMDs) in an aqueous solution. The multivalent hydrogen bonding of dextran with bulk TMDs (WS<sub>2</sub>, WSe<sub>2</sub>, and MoSe<sub>2</sub>) in liquid exfoliation effectively produces TMD monolayers with binding multivalency for pathogenic bacteria. Density functional theory simulation reveals that the multivalent hydrogen bonding between dextran and TMD monolayers is very strong and thermodynamically favored (ΔE<sub>b</sub> = -0.52 eV). The resulting dextran/TMD hybrids (dex-TMDs) exhibit a stronger affinity (K<sub>d</sub> = 11 nM) to Escherichia coli O157:H7 (E. coli) than E. coli-specific antibodies and aptamers. The dex-TMDs can effectively detect a single copy of E. coli based on their Raman signal.
Medical subject headings
- Biosensing Techniques
- Chalcogens
- Coordination Complexes
- Dextrans
- Escherichia coli O157
- Nanostructures