Sarcoidosis in Patients with Antisynthetase Syndrome: Presentation and Outcome.
retrospective_cohort · Level III
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- Record sourced from PubMed, PMID 29961694.
- Also identified by DOI 10.3899/jrheum.171098.
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Abstract
To investigate the uncommon co-occurrence of antisynthetase syndrome (AS) and sarcoidosis. From 2000 to 2015, patients with sarcoidosis were extracted from a retrospective multicentric cohort of 352 patients with AS. Ten patients (2.8%; 6 men, 8 whites, 5 smokers, median age 50 yrs) had both AS and sarcoidosis. Most of the time, sarcoidosis and AS occurred simultaneously (n = 7). Antibody testing revealed anti-Jo1 (n = 5), anti-PL12 (n = 4), or anti-PL7 (n = 1). Finally, no patient had a worsening of muscular condition, 5 patients presented respiratory deterioration, 3 remained stable, and 2 showed improvement. Sarcoidosis may be underdiagnosed in patients with AS.
Medical subject headings
- Antibodies, Antinuclear
- Autoantibodies
- Myositis
- Sarcoidosis