Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates.

Dudley, Dawn M; Van Rompay, Koen K; Coffey, Lark L; Ardeshir, Amir; Keesler, Rebekah I; Bliss-Moreau, Eliza; Grigsby, Peta L; Steinbach, Rosemary J et al. · Nat Med · 2018

basic_science · Level V

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Abstract

Zika virus (ZIKV) infection is associated with congenital defects and pregnancy loss. Here, we found that 26% of nonhuman primates infected with Asian/American ZIKV in early gestation experienced fetal demise later in pregnancy despite showing few clinical signs of infection. Pregnancy loss due to asymptomatic ZIKV infection may therefore be a common but under-recognized adverse outcome related to maternal ZIKV infection.

Medical subject headings