A Glycolysis Outsider Steps into the Cancer Spotlight.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 29972796.
- Also identified by DOI 10.1016/j.cmet.2018.06.017.
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Abstract
Glycolysis is prudently regulated and coupled to cell growth. Phosphofructokinase 2 controls glycolytic flux by generating fructose 2,6-bisphosphate, an allosteric activator of phosphofructokinase 1. In a recent paper in Nature, Dasgupta et al. address the novel role of PFKFB4, an isoform of phosphofructokinase 2, in regulating gene expression to promote tumor growth.
Medical subject headings
- Breast Neoplasms
- Glycolysis