Melanin-Concentrating Hormone-Dependent Control of Feeding: When Volume Matters.

Jiang, Hong; Brüning, Jens C · Cell Metab · 2018

editorial · Level V

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Abstract

In contrast to synaptic transmission, the mechanism of volume transmission-in which neurotransmitters or neuropeptides diffuse to many effector cells-is not extensively investigated, although it represents an important mode of neuronal communication. In this issue of Cell Metabolism, Noble et al. (2018) demonstrate how the orexigenic melanin-concentrating hormone (MCH) controls feeding behavior through cerebrospinal fluid (CSF) volume transmission.

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