Opioid-Induced Adrenal Insufficiency.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 29976376.
- Also identified by DOI 10.1016/j.mayocp.2018.04.010.
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Abstract
One in 10 Americans experience chronic pain. Although opioids do play a role in the management of pain, long-term opioid use may lead to adverse effects. Endocrine-related adverse effects have been described but remain poorly recognized. Opioid-induced adrenal insufficiency occurs because of suppression of hypothalamic-pituitary-adrenal communication and may be challenging to diagnose but has been reported in 9% to 29% of patients receiving long-term opiate therapy. Little data exist to guide case detection and patient management. Treatment includes cessation of opiates (the inciting factor) if possible and glucocorticoid replacement.
Medical subject headings
- Adrenal Insufficiency
- Analgesics, Opioid