Insights into Trace Metal Metabolism in Health and Disease from PET: "PET Metallomics".
Where this comes from
- Record sourced from PubMed, PMID 29976696.
- Also identified by DOI 10.2967/jnumed.118.212803 and PMC identifier 6126445.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Essential trace metals such as copper, zinc, iron, and manganese perform critical functions in cellular and physiologic processes including catalytic, regulatory, and signaling roles. Disturbed metal homeostasis is associated with the pathogenesis of diseases such as dementia, cancer, and inherited metabolic abnormalities. Intracellular pathways involving essential metals have been extensively studied but whole-body fluxes and transport between different compartments remain poorly understood. The growing availability of PET scanners and positron-emitting isotopes of key essential metals, particularly <sup>64</sup>Cu, <sup>63</sup>Zn, and <sup>52</sup>Mn, provide new tools with which to study these processes in vivo. This review highlights opportunities that now present themselves, exemplified by studies of copper metabolism that are in the vanguard of a new research front in molecular imaging: "PET metallomics."
Medical subject headings
- Disease
- Health
- Positron-Emission Tomography
- Trace Elements