<sup>68</sup>Ga-PSMA-11 PET/CT in Primary and Recurrent Prostate Carcinoma: Implications for Radiotherapeutic Management in 121 Patients.
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- Also identified by DOI 10.2967/jnumed.118.211086 and PMC identifier 8833857.
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Abstract
The present study analyzed the impact of Gallium-68 (<sup>68</sup>Ga)-labeled prostate-specific membrane antigen-HBED-CC (<sup>68</sup>Ga-PSMA-11) positron-emission tomography (PET)/computed tomography (CT) on radiotherapeutic management in a large cohort of men with primary or recurrent disease. <b>Methods:</b> This study investigated 121 men with carcinoma of the prostate who underwent <sup>68</sup>Ga-PSMA-11 PET/CT as well as conventional imaging. 50 patients were treatment naive, 11 had persistent prostate-specific antigen (PSA) soon after surgery and 60 presented with recurrent PSA following definitive therapy. Changes in TNM classification of malignant tumors (TNM) stage and radiotherapeutic management after <sup>68</sup>Ga-PSMA-11 imaging were compared to results achieved with conventional imaging. <b>Results:</b> In total, a change in TNM stage and radiotherapeutic management was observed for 49 patients (40.5%) and 62 patients (51.2%), respectively. In treatment naïve patients, a change in TNM stage and radiotheraeutic plan occurred in 26.0% and 44.0% of the cohort respectively. For patients with PSA persistence or recurrence, TNM and radiotherapeutic management changed in 50.7% and 56.3% respectively. <b>Conclusion:</b><sup>68</sup>Ga-PSMA-11 PET/CT may shortly become an indispensable tool for detecting prostate cancer lesions in treatment-naïve patients as well as in men with recurrent disease or persistent PSA and seems to be very helpful in personalizing radiotherapeutic management to the individual patients' distribution of disease.