T-Cell Receptor Excision Circles in HIV-Exposed, Uninfected Newborns Measured During a National Newborn Screening Program for Severe Combined Immunodeficiency.

Warszawski, Josiane; Thomas, Caroline; Dialla, Olivia; Garrait, Valérie; Dollfus, Catherine; Reliquet, Veronique; Clech, Laure; Dert, Cécile et al. · J Pediatr · 2018

cross_sectional · Level IV

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Abstract

Severe combined immunodeficiency screening by measuring T-receptor excision circles at birth allows evaluation of the impact of various maternal conditions on newborn immunity. The slight decrease observed in a French cohort of newborns to HIV-infected mothers can be explained by the confounding factors of prematurity and African descent.

Medical subject headings