Neoantigens in Ovarian Cancer: Embarrassment of Riches or Needles in a Haystack?
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 29980529.
- Also identified by DOI 10.1158/1078-0432.CCR-18-1731 and PMC identifier 6215482.
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Abstract
Comprehensive genomic and transcriptomic analysis demonstrate that tumor-infiltrating T lymphocytes that react to mutated neoepitopes could be identified in recurrent ovarian cancer. Two of these T-cell populations reacted against <i>TP53</i> hotspot missense mutations that are present in a wide variety of malignancies. <i>Clin Cancer Res; 24(22); 5493-5. ©2018 AACR</i> <i>See related article by Deniger et al., p. 5562</i>.
Medical subject headings
- Embarrassment
- Ovarian Neoplasms