Silver-catalyzed remote Csp<sup>3</sup>-H functionalization of aliphatic alcohols.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29980674.
- Also identified by DOI 10.1038/s41467-018-05014-w and PMC identifier 6035238.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Aliphatic alcohols are common and bulk chemicals in organic synthesis. The site-selective functionalization of non-activated aliphatic alcohols is attractive but challenging. Herein, we report a silver-catalyzed δ-selective Csp<sup>3</sup>-H bond functionalization of abundant and inexpensive aliphatic alcohols. Valuable oximonitrile substituted alcohols are easily obtained by using well-designed sulphonyl reagents under simple and mild conditions. This protocol realizes the challenging δ-selective C-C bond formation of simple alkanols.